Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

The use of proteasome inhibitors to target cancer’s dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits...

Full description

Bibliographic Details
Main Authors: Tsvetkov, Peter, Brune, Zarina, Thiru, Prathapan, Ghandi, Mahmoud, Santagata, Sandro, Whitesell, Luke, Sokol, Ethan Samuel, Jin, Dexter X., Gupta, Piyush, Lindquist, Susan, Garraway, Levi A.
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/111198
https://orcid.org/0000-0002-2988-0537
https://orcid.org/0000-0003-1533-6730
https://orcid.org/0000-0002-9703-1780
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/111198
https://orcid.org/0000-0002-2988-0537
https://orcid.org/0000-0003-1533-6730
https://orcid.org/0000-0002-9703-1780
https://orcid.org/0000-0003-1307-882X

Similar Items