Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers

The use of proteasome inhibitors to target cancer’s dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits...

書目詳細資料
Main Authors:	Tsvetkov, Peter, Brune, Zarina, Thiru, Prathapan, Ghandi, Mahmoud, Santagata, Sandro, Whitesell, Luke, Sokol, Ethan Samuel, Jin, Dexter X., Gupta, Piyush, Lindquist, Susan, Garraway, Levi A.
其他作者:	Broad Institute of MIT and Harvard
格式:	Article
語言:	en_US
出版:	National Academy of Sciences (U.S.) 2017
在線閱讀:	http://hdl.handle.net/1721.1/111198 https://orcid.org/0000-0002-2988-0537 https://orcid.org/0000-0003-1533-6730 https://orcid.org/0000-0002-9703-1780 https://orcid.org/0000-0003-1307-882X

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