A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

X-chromosome inactivation is a mechanism of dosage compensation in which one of the two X chromosomes in female mammals is transcriptionally silenced. Once established, silencing of the inactive X (Xi) is robust and difficult to reverse pharmacologically. However, the Xi is a reservoir of >1,000...

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Bibliographic Details
Main Authors: Lessing, Derek, Dial, Thomas O., Wei, Chunyao, Payer, Bernhard, Carrette, Lieselot L. G., Kesner, Barry, Szanto, Attila, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Theriault, Jimmy, Hasaka, Thomas, Bedalov, Antonio, Bartolomei, Marisa S., Lee, Jeannie T.
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/111199

Internet

http://hdl.handle.net/1721.1/111199

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