Systematic dissection of genomic features determining transcription factor binding and enhancer function

Systematic dissection of genomic features determining transcription factor binding and enhancer function

Enhancers regulate gene expression through the binding of sequence-specific transcription factors (TFs) to cognate motifs. Various features influence TF binding and enhancer function—including the chromatin state of the genomic locus, the affinities of the binding site, the activity of the bound TFs...

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Bibliographic Details
Main Authors: Zhang, Xiaolan, Wang, Li, Melnikov, Alexandre, Rogov, Peter, Tewhey, Ryan, Isakova, Alina, Deplancke, Bart, Bernstein, Bradley E., Mikkelsen, Tarjei S., Grossman, Sharon Rachel, Engreitz, Jesse Michael, Lander, Eric Steven
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/111218
https://orcid.org/0000-0001-5410-7274
https://orcid.org/0000-0002-5754-1719

Internet

http://hdl.handle.net/1721.1/111218
https://orcid.org/0000-0001-5410-7274
https://orcid.org/0000-0002-5754-1719

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