Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Fever is a universal response to infection, and opportunistic pathogens such as Candida albicans have evolved complex circuitry to sense and respond to heat. Here we harness RNA-seq and ChIP-seq to discover that the heat shock transcription factor, Hsf1, binds distinct motifs in nucleosome-depleted...

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Bibliographic Details
Main Authors: Leach, Michelle D., Tan, Kaeling, Miao, Zhengqiang, Walker, Louise A., Cuomo, Christina A., Wheeler, Robert T., Brown, Alistair J. P., Wong, Koon Ho, Cowen, Leah E., Farrer, Rhys
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/111593
https://orcid.org/0000-0002-3710-9881

Internet

http://hdl.handle.net/1721.1/111593
https://orcid.org/0000-0002-3710-9881

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