β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X

β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X

Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of autism and intellectual disability. Neural activity directs local protein synthesis via activation of metabotropi...

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Bibliographic Details
Main Authors: Auerbach, Benjamin D., Lefkowitz, Robert J., Stoppel, Laura Jane, Senter, Rebecca K, Preza, Anthony R., Bear, Mark
Other Authors: Picower Institute for Learning and Memory
Format: Article
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/111663
https://orcid.org/0000-0001-6673-4988

Internet

http://hdl.handle.net/1721.1/111663
https://orcid.org/0000-0001-6673-4988

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