Synergistic interactions with PI3K inhibition that induce apoptosis

Synergistic interactions with PI3K inhibition that induce apoptosis

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K muta...

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Bibliographic Details
Main Authors: Zwang, Yaara, Chen, Casandra, Rinne, Mikael L, Doench, John G, Piccioni, Federica, Tan, Li, Huang, Hai-Tsang, Wang, Jinhua, Ham, Young Jin, O'Connell, Joyce, Bhola, Patrick, Doshi, Mihir, Whitman, Matthew, Letai, Anthony, Root, David E, Gray, Nathanael, Hahn, William C, Jonas, Oliver H., Langer, Robert S, Cima, Michael J.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Published: eLife Sciences Publications, Ltd 2017
Online Access:http://hdl.handle.net/1721.1/111792
https://orcid.org/0000-0003-2512-2007
https://orcid.org/0000-0003-2379-6139
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/111792
https://orcid.org/0000-0003-2512-2007
https://orcid.org/0000-0003-2379-6139
https://orcid.org/0000-0003-4255-0492

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