Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore–antibiotic conjugates
The syntheses of five ciprofloxacin-modified (acyloxyl)alkyl esters and two siderophore–ciprofloxacin conjugates based on enterobactin that harbor such hydrolyzable linkages are reported. The hydrolytic stabilities of ciprofloxacin-modified (acyloxy)alkyl esters, evaluated at pH 7.5 and 30 °C, vary...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2017
|
| Online Access: | http://hdl.handle.net/1721.1/112091 https://orcid.org/0000-0002-6153-8803 |