Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB dysfunction exists in neurological disorders, including Huntington's disease (HD), it is not known if BMECs themselves are...

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Bibliographic Details
Main Authors: Lim, Ryan G., Quan, Chris, Reyes-Ortiz, Andrea M., Lutz, Sarah E., Kedaigle, Amanda J., Wu, Jie, Vatine, Gad D., Stocksdale, Jennifer, Casale, Malcolm S., Svendsen, Clive N., Fraenkel, Ernest, Agalliu, Dritan, Thompson, Leslie M., Wasylenko, Theresa Anne, Housman, David E
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/112100
https://orcid.org/0000-0002-0524-5301
https://orcid.org/0000-0001-5016-0756

Internet

http://hdl.handle.net/1721.1/112100
https://orcid.org/0000-0002-0524-5301
https://orcid.org/0000-0001-5016-0756

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