Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism
Background Individuals with reading disability and individuals with autism spectrum disorder (ASD) are characterized, respectively, by their difficulties in reading and social communication, but both groups often have impaired phonological working memory (PWM). It is not known whether the impaired P...
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112144 https://orcid.org/0000-0002-4812-8842 https://orcid.org/0000-0002-9149-1815 https://orcid.org/0000-0001-6290-1160 https://orcid.org/0000-0003-1158-5692 |
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| author | Harris, Adrianne Wisman Weil, Lisa Tager-Flusberg, Helen Lu, Chunming Qi, Zhenghan Han, Michelle Halverson, Kelly Perrachione, Tyler Kent Kjelgaard, Margaret McCaughin Wexler, Kenneth N Gabrieli, John D. E. |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Harris, Adrianne Wisman Weil, Lisa Tager-Flusberg, Helen Lu, Chunming Qi, Zhenghan Han, Michelle Halverson, Kelly Perrachione, Tyler Kent Kjelgaard, Margaret McCaughin Wexler, Kenneth N Gabrieli, John D. E. |
| author_sort | Harris, Adrianne |
| collection | MIT |
| description | Background Individuals with reading disability and individuals with autism spectrum disorder (ASD) are characterized, respectively, by their difficulties in reading and social communication, but both groups often have impaired phonological working memory (PWM). It is not known whether the impaired PWM reflects distinct or shared neuroanatomical abnormalities in these two diagnostic groups. Methods White-matter structural connectivity via diffusion weighted imaging was examined in 64 children, age 5 to 17 years, with reading disability, ASD, or typical development, who were matched on age, gender, intelligence, and diffusion data quality. Results Children with reading disability and children with ASD exhibited reduced PWM compared with children with typical development. The two diagnostic groups showed altered white matter microstructure in the temporoparietal portion of the left arcuate fasciculus and in the occipitotemporal portion of the right inferior longitudinal fasciculus (ILF), as indexed by reduced fractional anisotropy and increased radial diffusivity. Moreover, the structural integrity of the right ILF was positively correlated with PWM ability in the two diagnostic groups but not in the typically developing group. Conclusions These findings suggest that impaired PWM is transdiagnostically associated with shared neuroanatomical abnormalities in ASD and reading disability. Microstructural characteristics in left arcuate fasciculus and right ILF may play important roles in the development of PWM. The right ILF may support a compensatory mechanism for children with impaired PWM. |
| first_indexed | 2024-09-23T11:30:46Z |
| format | Article |
| id | mit-1721.1/112144 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:30:46Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1121442022-10-01T04:06:02Z Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism Harris, Adrianne Wisman Weil, Lisa Tager-Flusberg, Helen Lu, Chunming Qi, Zhenghan Han, Michelle Halverson, Kelly Perrachione, Tyler Kent Kjelgaard, Margaret McCaughin Wexler, Kenneth N Gabrieli, John D. E. McGovern Institute for Brain Research at MIT Lu, Chunming Qi, Zhenghan Han, Michelle Halverson, Kelly Perrachione, Tyler Kent Kjelgaard, Margaret McCaughin Wexler, Kenneth N Gabrieli, John D. E. Background Individuals with reading disability and individuals with autism spectrum disorder (ASD) are characterized, respectively, by their difficulties in reading and social communication, but both groups often have impaired phonological working memory (PWM). It is not known whether the impaired PWM reflects distinct or shared neuroanatomical abnormalities in these two diagnostic groups. Methods White-matter structural connectivity via diffusion weighted imaging was examined in 64 children, age 5 to 17 years, with reading disability, ASD, or typical development, who were matched on age, gender, intelligence, and diffusion data quality. Results Children with reading disability and children with ASD exhibited reduced PWM compared with children with typical development. The two diagnostic groups showed altered white matter microstructure in the temporoparietal portion of the left arcuate fasciculus and in the occipitotemporal portion of the right inferior longitudinal fasciculus (ILF), as indexed by reduced fractional anisotropy and increased radial diffusivity. Moreover, the structural integrity of the right ILF was positively correlated with PWM ability in the two diagnostic groups but not in the typically developing group. Conclusions These findings suggest that impaired PWM is transdiagnostically associated with shared neuroanatomical abnormalities in ASD and reading disability. Microstructural characteristics in left arcuate fasciculus and right ILF may play important roles in the development of PWM. The right ILF may support a compensatory mechanism for children with impaired PWM. 2017-11-08T16:41:05Z 2017-11-08T16:41:05Z 2015-11 2015-11 2017-11-07T19:24:19Z Article http://purl.org/eprint/type/JournalArticle 2451-9022 http://hdl.handle.net/1721.1/112144 Lu, Chunming et al. “Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism.” Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 1, 2 (March 2016): 169–177 © 2016 Society of Biological Psychiatry https://orcid.org/0000-0002-4812-8842 https://orcid.org/0000-0002-9149-1815 https://orcid.org/0000-0001-6290-1160 https://orcid.org/0000-0003-1158-5692 http://dx.doi.org/10.1016/J.BPSC.2015.11.001 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Harris, Adrianne Wisman Weil, Lisa Tager-Flusberg, Helen Lu, Chunming Qi, Zhenghan Han, Michelle Halverson, Kelly Perrachione, Tyler Kent Kjelgaard, Margaret McCaughin Wexler, Kenneth N Gabrieli, John D. E. Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism |
| title | Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism |
| title_full | Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism |
| title_fullStr | Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism |
| title_full_unstemmed | Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism |
| title_short | Shared Neuroanatomical Substrates of Impaired Phonological Working Memory Across Reading Disability and Autism |
| title_sort | shared neuroanatomical substrates of impaired phonological working memory across reading disability and autism |
| url | http://hdl.handle.net/1721.1/112144 https://orcid.org/0000-0002-4812-8842 https://orcid.org/0000-0002-9149-1815 https://orcid.org/0000-0001-6290-1160 https://orcid.org/0000-0003-1158-5692 |
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