Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) stretch within the Huntingtin (Htt) protein. Pathogenic Htt disrupts multiple neuronal processes, including gene expression, axonal trafficking, proteasome and mitochondrial activity, and intrace...
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| Format: | Article |
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Society for Neuroscience
2017
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| Online Access: | http://hdl.handle.net/1721.1/112213 https://orcid.org/0000-0001-5576-2887 |