G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress
Oxidative DNA damage is an implacable consequence of aerobic metabolism and often exacerbated in inflammatory processes that use reactive oxygen species (ROS) both as signaling molecules and as chemical warfare against pathogens. An extensive body of work, recently reviewed in ref. 1, has highlighte...
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| Format: | Article |
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National Academy of Sciences (U.S.)
2017
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| Online Access: | http://hdl.handle.net/1721.1/112221 https://orcid.org/0000-0001-5252-826X |
| _version_ | 1826215298560163840 |
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| author | Fedeles, Bogdan I |
| author2 | Massachusetts Institute of Technology. Center for Environmental Health Sciences |
| author_facet | Massachusetts Institute of Technology. Center for Environmental Health Sciences Fedeles, Bogdan I |
| author_sort | Fedeles, Bogdan I |
| collection | MIT |
| description | Oxidative DNA damage is an implacable consequence of aerobic metabolism and often exacerbated in inflammatory processes that use reactive oxygen species (ROS) both as signaling molecules and as chemical warfare against pathogens. An extensive body of work, recently reviewed in ref. 1, has highlighted the deleterious consequences of oxidative DNA damage, which involves oxidized nucleobases that, if left unrepaired, are either mutagenic or strong replication blockers. Most oxidative DNA damage is efficiently processed by DNA repair pathways, primarily base excision repair (BER), the molecular details of which are generally well understood (2). However, an emerging area of research posits that certain oxidative DNA lesions and their associated repair complexes are intermediates in a signaling transduction cascade that uses ROS as secondary messengers to ultimately effect transcriptional regulation (3⇓⇓⇓–7). In PNAS, Fleming et al. (8) reinforce these notions by describing a compelling mechanism by which 8-oxoguanine (OG), a canonical oxidative DNA damage product, when occurring in guanine-rich, G-quadruplex–forming promoter sequences, directly up-regulates transcription of the downstream gene. |
| first_indexed | 2024-09-23T16:22:30Z |
| format | Article |
| id | mit-1721.1/112221 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:22:30Z |
| publishDate | 2017 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/1122212022-10-02T07:51:52Z G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress Fedeles, Bogdan I Massachusetts Institute of Technology. Center for Environmental Health Sciences Massachusetts Institute of Technology. Department of Biological Engineering Fedeles, Bogdan I Oxidative DNA damage is an implacable consequence of aerobic metabolism and often exacerbated in inflammatory processes that use reactive oxygen species (ROS) both as signaling molecules and as chemical warfare against pathogens. An extensive body of work, recently reviewed in ref. 1, has highlighted the deleterious consequences of oxidative DNA damage, which involves oxidized nucleobases that, if left unrepaired, are either mutagenic or strong replication blockers. Most oxidative DNA damage is efficiently processed by DNA repair pathways, primarily base excision repair (BER), the molecular details of which are generally well understood (2). However, an emerging area of research posits that certain oxidative DNA lesions and their associated repair complexes are intermediates in a signaling transduction cascade that uses ROS as secondary messengers to ultimately effect transcriptional regulation (3⇓⇓⇓–7). In PNAS, Fleming et al. (8) reinforce these notions by describing a compelling mechanism by which 8-oxoguanine (OG), a canonical oxidative DNA damage product, when occurring in guanine-rich, G-quadruplex–forming promoter sequences, directly up-regulates transcription of the downstream gene. 2017-11-17T15:33:52Z 2017-11-17T15:33:52Z 2017-03 2017-10-30T16:33:58Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/112221 Fedeles, Bogdan I. “G-Quadruplex–forming Promoter Sequences Enable Transcriptional Activation in Response to Oxidative Stress.” Proceedings of the National Academy of Sciences 114, 11 (March 2017): 2788–2790 © 2017 National Academy of Sciences https://orcid.org/0000-0001-5252-826X http://dx.doi.org/10.1073/pnas.1701244114 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Fedeles, Bogdan I G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress |
| title | G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress |
| title_full | G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress |
| title_fullStr | G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress |
| title_full_unstemmed | G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress |
| title_short | G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress |
| title_sort | g quadruplex forming promoter sequences enable transcriptional activation in response to oxidative stress |
| url | http://hdl.handle.net/1721.1/112221 https://orcid.org/0000-0001-5252-826X |
| work_keys_str_mv | AT fedelesbogdani gquadruplexformingpromotersequencesenabletranscriptionalactivationinresponsetooxidativestress |