Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method...

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Bibliographic Details
Main Authors: Noh, Hyun Ji, Flannick, Jason, O’Dushlaine, Colm, Swofford, Ross, Howrigan, Daniel, Genereux, Diane P., Johnson, Jeremy, van Grootheest, Gerard, Grünblatt, Edna, Andersson, Erik, Djurfeldt, Diana R., Patel, Paresh D., Koltookian, Michele, M. Hultman, Christina, Pato, Michele T., Pato, Carlos N., Rasmussen, Steven A., Jenike, Michael A., Hanna, Gregory L., Stewart, S. Evelyn, Knowles, James A., Ruhrmann, Stephan, Grabe, Hans-Jörgen, Wagner, Michael, Rück, Christian, Mathews, Carol A., Walitza, Susanne, Cath, Daniëlle C., Lindblad-Toh, Kerstin, Tang, Ruqi, Feng, Guoping, Karlsson, Elinor
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/112251
https://orcid.org/0000-0002-8021-277X

Internet

http://hdl.handle.net/1721.1/112251
https://orcid.org/0000-0002-8021-277X

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