Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

De novo mutations in CHD8 are strongly associated with autism spectrum disorder, but the basic biology of CHD8 remains poorly understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor proliferation and differentiation that ultimately manifests...

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Bibliographic Details
Main Authors: Durak, Omer, Gao, Fan, Kaeser-Woo, Yea Jin, Rueda IV, Richard, Martorell, Anthony, Nott, Alexander, Liu, Carol Y, Watson, Lauren Ashley, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/112696
https://orcid.org/0000-0001-8426-6188
https://orcid.org/0000-0001-9225-3221
https://orcid.org/0000-0002-2206-2590
https://orcid.org/0000-0002-2029-7193
https://orcid.org/0000-0003-1262-0592

Internet

http://hdl.handle.net/1721.1/112696
https://orcid.org/0000-0001-8426-6188
https://orcid.org/0000-0001-9225-3221
https://orcid.org/0000-0002-2206-2590
https://orcid.org/0000-0002-2029-7193
https://orcid.org/0000-0003-1262-0592

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