Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

A short half-life in the circulation limits the application of therapeutics such as single-domain antibodies (VHHs). We utilize red blood cells to prolong the circulatory half-life of VHHs. Here we present VHHs against botulinum neurotoxin A (BoNT/A) on the surface of red blood cells by expressing c...

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Bibliographic Details
Main Authors: Huang, Nai-Jia, Mukherjee, Jean, Zhang, Sicai, Shoemaker, Charles B., Pishesha, Novalia, Deshycka, Rhogerry, Sudaryo, Valentino, Lodish, Harvey F, Dong, Min, 1968-
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/112702
https://orcid.org/0000-0001-9306-8271
https://orcid.org/0000-0002-5816-9955
https://orcid.org/0000-0002-7029-7415

Internet

http://hdl.handle.net/1721.1/112702
https://orcid.org/0000-0001-9306-8271
https://orcid.org/0000-0002-5816-9955
https://orcid.org/0000-0002-7029-7415

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