Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin
A short half-life in the circulation limits the application of therapeutics such as single-domain antibodies (VHHs). We utilize red blood cells to prolong the circulatory half-life of VHHs. Here we present VHHs against botulinum neurotoxin A (BoNT/A) on the surface of red blood cells by expressing c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112702 https://orcid.org/0000-0001-9306-8271 https://orcid.org/0000-0002-5816-9955 https://orcid.org/0000-0002-7029-7415 |