Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, only two Class 2 effectors, Cas9 and Cpf1, are known. We describe here three distinct Class 2 CRISPR-Cas systems. The effectors of two of the identified...

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Bibliographic Details
Main Authors: Shmakov, Sergey, Makarova, Kira S., Wolf, Yuri I., Semenova, Ekaterina, Minakhin, Leonid, Severinov, Konstantin, Koonin, Eugene V., Abudayyeh, Omar Osama, Gootenberg, Jonathan S, Joung, Julia, Konermann, Silvana M, Zhang, Feng
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/112723
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0001-7915-1685
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/112723
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0001-7915-1685
https://orcid.org/0000-0003-2782-2509

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