Crystal Structure of Staphylococcus aureus Cas9

Summary The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent mot if (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to fac...

Full description

Bibliographic Details
Main Authors: Nishimasu, Hiroshi, Ran, F. Ann, Kurabayashi, Arisa, Ishitani, Ryuichiro, Nureki, Osamu, Cong, Le, Yan, Winston Xia, Zetsche, Bernd, Li, Yinqing, Zhang, Feng
Other Authors: Institute for Medical Engineering and Science
Format: Article
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/112724
https://orcid.org/0000-0002-3067-479X
https://orcid.org/0000-0003-2782-2509