High-resolution interrogation of functional elements in the noncoding genome

High-resolution interrogation of functional elements in the noncoding genome

The noncoding genome affects gene regulation and disease, yet we lack tools for rapid identification and manipulation of noncoding elements. We developed a CRISPR screen using ∼18,000 single guide RNAs targeting > 700 kilobases surrounding the genes NF1, NF2, and CUL3, which are involved in BRAF...

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Bibliographic Details
Main Authors: Fontanillas, P., Sanjana, Neville E, Wright, Jason, Zheng, Kaijie, Shalem, Ophir, Joung, Julia, Cheng, Chia-Wei, Regev, Aviv, Zhang, Feng
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: American Association for the Advancement of Science (AAAS) 2017
Online Access:http://hdl.handle.net/1721.1/112731
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0003-1088-923X
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/112731
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0003-1088-923X
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0003-2782-2509

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