Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Forward genetic screens are powerful tools for the unbiased discovery and functional characterization of specific genetic elements associated with a phenotype of interest. Recently, the RNA-guided endonuclease Cas9 from the microbial CRISPR (clustered regularly interspaced short palindromic repeats)...

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Bibliographic Details
Main Authors: Joung, Julia, Konermann, Silvana M, Gootenberg, Jonathan S, Abudayyeh, Omar Osama, Platt, Randall Jeffrey, Brigham, Mark D, Sanjana, Neville E, Zhang, Feng
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Published: Springer Nature 2017
Online Access:http://hdl.handle.net/1721.1/112748
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0001-7915-1685
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/112748
https://orcid.org/0000-0001-6656-5002
https://orcid.org/0000-0001-7915-1685
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0003-2782-2509

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