Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL contacts genome-wide in single human cells. Analysis of nearly 400 maps reveals a core architecture consisting of gene-poor LADs that contac...

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Bibliographic Details
Main Authors: Kind, Jop, Pagie, Ludo, de Vries, Sandra S., Nahidiazar, Leila, Dey, Siddharth S., Bienko, Magda, Zhan, Ye, Lajoie, Bryan, de Graaf, Carolyn A., Amendola, Mario, Jalink, Kees, Dekker, Job, van Oudenaarden, Alexander, van Steensel, Bas, Fudenberg, Geoffrey, Imakaev, Maksim Viktorovich, Mirny, Leonid A
Other Authors: Massachusetts Institute of Technology. Department of Physics
Format: Article
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/112800
https://orcid.org/0000-0001-5905-6517
https://orcid.org/0000-0002-5320-2728
https://orcid.org/0000-0002-0785-5410

Internet

http://hdl.handle.net/1721.1/112800
https://orcid.org/0000-0001-5905-6517
https://orcid.org/0000-0002-5320-2728
https://orcid.org/0000-0002-0785-5410

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