PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large...

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Bibliographic Details
Main Authors: Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Proceedings of the National Academy of Sciences 2017
Online Access:http://hdl.handle.net/1721.1/112943
https://orcid.org/0000-0003-3688-2378
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/112943
https://orcid.org/0000-0003-3688-2378
https://orcid.org/0000-0002-1446-7256

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