Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteostasis pathways are principal determinants of starva...

Full description

Bibliographic Details
Main Authors: Webster, Christopher M., Pino, Elizabeth C., Wu, Lianfeng, Zhou, Ben, Cedillo, Lucydalila, Kacergis, Michael C., Curran, Sean P., Soukas, Alexander A., Carr, Christopher E.
Other Authors: Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/113267

Internet

http://hdl.handle.net/1721.1/113267

Similar Items