Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors
Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI in vivo. Herein, we report nitroxide-functionalized brush-arm star polymer organic radical contrast agents...
Main Authors: | Paletta, Joseph T., Zhang, Hui, Boska, Michael D., Ottaviani, M. Francesca, Rajca, Andrzej, Nguyen, Hung VanThanh, Chen, Qixian, Harvey, Peter, Jiang, Yivan, Jasanoff, Alan Pradip, Johnson, Jeremiah A. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Published: |
American Chemical Society (ACS)
2018
|
Online Access: | http://hdl.handle.net/1721.1/113328 https://orcid.org/0000-0002-6945-4057 https://orcid.org/0000-0002-8163-7059 https://orcid.org/0000-0002-2834-6359 https://orcid.org/0000-0001-9157-6491 |
Similar Items
-
Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors
by: Hung V.-T. Nguyen, et al.
Published: (2017-07-01) -
Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging
by: Nguyen, Hung VanThanh, et al.
Published: (2020) -
Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems
by: Nguyen, Hung VanThanh, et al.
Published: (2020) -
A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence
by: Shiwei Guo, et al.
Published: (2021-08-01) -
Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents
by: Alvaradejo, Gabriela Gil, et al.
Published: (2020)