The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility

The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility

Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense protein that is involved in the metal-withholding innate immune response. CP coordinates a variety of divalent first-row transition metal ions, which is implicated in its antimicrobial function, and it...

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Bibliographic Details
Main Authors: Keegan, Brenna C., Shearer, Jason M., Nakashige, Toshiki George, Stephan, Jules Rabie, Cunden, Lisa Stephanie, Brophy, Megan Brunjes, Wommack, Andrew, Nolan, Elizabeth Marie
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Published: American Chemical Society (ACS) 2018
Online Access:http://hdl.handle.net/1721.1/113417
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0001-7738-5728
https://orcid.org/0000-0002-1733-9874
https://orcid.org/0000-0002-6153-8803

Internet

http://hdl.handle.net/1721.1/113417
https://orcid.org/0000-0002-6234-8155
https://orcid.org/0000-0001-7738-5728
https://orcid.org/0000-0002-1733-9874
https://orcid.org/0000-0002-6153-8803

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