The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility
Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense protein that is involved in the metal-withholding innate immune response. CP coordinates a variety of divalent first-row transition metal ions, which is implicated in its antimicrobial function, and it...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
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American Chemical Society (ACS)
2018
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| Online Access: | http://hdl.handle.net/1721.1/113417 https://orcid.org/0000-0002-6234-8155 https://orcid.org/0000-0001-7738-5728 https://orcid.org/0000-0002-1733-9874 https://orcid.org/0000-0002-6153-8803 |