Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Culture-based blood-brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro barrier properties and permeability remain as major challenges. Here, we report that self-Assembling multicellular BBB spheroids display reprodu...

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Bibliographic Details
Main Authors: Calligaris, David, Hornburg, Kalvis, Chiocca, E. Antonio, Agar, Nathalie Y. R., Lawler, Sean E., Cho, Choi-Fong, Wolfe, Justin, Fadzen, Colin M., Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/113429
https://orcid.org/0000-0001-9811-4396
https://orcid.org/0000-0002-1003-6045
https://orcid.org/0000-0002-4139-9578

Internet

http://hdl.handle.net/1721.1/113429
https://orcid.org/0000-0001-9811-4396
https://orcid.org/0000-0002-1003-6045
https://orcid.org/0000-0002-4139-9578

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