Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is...

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Bibliographic Details
Main Authors: Redhu, Naresh S, Bakthavatchalu, Vasudevan, Conaway, Evan A, Shouval, Dror S, Tsou, Amy, Goettel, Jeremy A, Biswas, Amlan, Wang, Chuanwu, Field, Michael, Muller, Werner, Bleich, Andre, Li, Ning, Gerber, Georg K, Bry, Lynn, Fox, James G, Snapper, Scott B, Horwitz, Bruce H
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: eLife Sciences Publications, Ltd 2018
Online Access:http://hdl.handle.net/1721.1/113560
https://orcid.org/0000-0001-9850-161X
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/113560
https://orcid.org/0000-0001-9850-161X
https://orcid.org/0000-0001-9307-6116

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