Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
eLife Sciences Publications, Ltd
2018
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| Online Access: | http://hdl.handle.net/1721.1/113561 https://orcid.org/0000-0003-0606-9896 https://orcid.org/0000-0002-1719-5399 |