Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely cryptic, mechanisms for protein/lipid import...

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Bibliographic Details
Main Authors:	Amberg-Johnson, Katherine, Ganesan, Suresh M., Lorenzi, Hernan A., Niles, Jacquin C., Yeh, Ellen, Hari, Sanjay B., Sauer, Robert T.
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Published:	eLife Sciences Publications, Ltd 2018
Online Access:	http://hdl.handle.net/1721.1/113561 https://orcid.org/0000-0003-0606-9896 https://orcid.org/0000-0002-1719-5399

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