Deconstruction of the Ras switching cycle through saturation mutagenesis

Deconstruction of the Ras switching cycle through saturation mutagenesis

Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-dependent switching between active and inactive states. The high conservation of Ras requires mechanistic explanation, especially given the general mutational tolerance of proteins. Here, we use deep mutational...

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Bibliographic Details
Main Authors: Bandaru, Pradeep, Shah, Neel H, Bhattacharyya, Moitrayee, Barton, John P, Kondo, Yasushi, Cofsky, Joshua C, Gee, Christine L, Chakraborty, Arup K, Kortemme, Tanja, Ranganathan, Rama, Kuriyan, John
Other Authors: Institute for Medical Engineering and Science
Format: Article
Published: eLife Sciences Publications, Ltd 2018
Online Access:http://hdl.handle.net/1721.1/113564
https://orcid.org/0000-0003-1467-421X
https://orcid.org/0000-0003-1268-9602

Internet

http://hdl.handle.net/1721.1/113564
https://orcid.org/0000-0003-1467-421X
https://orcid.org/0000-0003-1268-9602

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