Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

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Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report...

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Bibliographic Details
Main Authors: Zhong, Wenhe, Cui, Liang, Goh, Boon Chong, Cai, Qixu, Ho, Peiying, Chionh, Yok Hian, Yuan, Meng, Sahili, Abbas El, Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Lescar, Julien, Dedon, Peter C
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/113572
https://orcid.org/0000-0003-0011-3067

Internet

http://hdl.handle.net/1721.1/113572
https://orcid.org/0000-0003-0011-3067

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