Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Nucleic acid therapeutics are limited by inefficient delivery to target tissues and cells and by an incomplete understanding of how nanoparticle structure affects biodistribution to off-target organs. Although thousands of nanoparticle formulations have been designed to deliver nucleic acids, most n...
Main Authors: | Kauffman, Kevin John, Xing, Yiping, Shaw, Taylor E., Mir, Faryal, Dlott, Chloe C., Langer, Robert S, Anderson, Daniel Griffith, Wang, Eric T, Dahlman, James E. |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2018
|
Online Access: | http://hdl.handle.net/1721.1/113871 https://orcid.org/0000-0002-9436-2453 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0001-5629-4798 |
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