Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

CRISPR-Cas adaptive immune systems defend microbes against foreign nucleic acids via RNA-guided endonucleases. Using a computational sequence database mining approach, we identify two class 2 CRISPR-Cas systems (subtype VI-B) that lack Cas1 and Cas2 and encompass a single large effector protein, Cas...

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Bibliographic Details
Main Authors: Shmakov, Sergey, Makarova, Kira S., Koonin, Eugene V., Smargon, Aaron Andrew, Cox, David Benjamin Turitz, Pyzocha, Neena, Zheng, Kaijie, Slaymaker, Ian, Gootenberg, Jonathan S, Essletzbichler, Patrick, Zhang, Feng, Abudayyeh, Omar O.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/114034
https://orcid.org/0000-0003-2986-4948
https://orcid.org/0000-0001-7626-4254
https://orcid.org/0000-0003-3310-6277
https://orcid.org/0000-0001-8794-2137
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/114034
https://orcid.org/0000-0003-2986-4948
https://orcid.org/0000-0001-7626-4254
https://orcid.org/0000-0003-3310-6277
https://orcid.org/0000-0001-8794-2137
https://orcid.org/0000-0002-7979-3220
https://orcid.org/0000-0003-2782-2509

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