The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance
Aneuploidy—or an unbalanced karyotype in which whole chromosomes are gained or lost—causes reduced fitness at both the cellular and organismal levels but is also a hallmark of human cancers. Aneuploidy causes a variety of cellular stresses, including genomic instability, proteotoxic and oxidative st...
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Cold Spring Harbor Laboratory
2018
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| Online Access: | http://hdl.handle.net/1721.1/114154 https://orcid.org/0000-0002-3129-8853 https://orcid.org/0000-0002-1501-6190 https://orcid.org/0000-0001-9837-0314 |