Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression

Extracellular matrix signals from the microenvironment regulate gene expression patterns and cell behavior. Using a combination of experiments and geometric models, we demonstrate correlations between cell geometry, three-dimensional (3D) organization of chromosome territories, and gene expression....

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Bibliographic Details
Main Authors: Wang, Yejun, Nagarajan, Mallika, Uhler, Caroline, Shivashankar, G. V.
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Published: American Society for Cell Biology (ASCB) 2018
Online Access:http://hdl.handle.net/1721.1/114156