Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics

Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics

Background The recently developed genetically encoded calcium indicator (GECI), called NTnC, has a novel design with reduced size due to utilization of the troponin C (TnC) as a Ca²⁺-binding moiety inserted into the mNeonGreen fluorescent protein. NTnC binds two times less Ca²⁺ ions...

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Main Authors: Doronin, D. A, Barykina, N. V, Subach, O. M, Sotskov, V. P, Plusnin, V. V, Ivleva, O. A, Isaakova, E. A, Varizhuk, A. M, Pozmogova, G. E, Malyshev, A. Y, Smirnov, I. V, Anokhin, K. V, Enikolopov, G. N, Subach, F. V, Doronin, D. A., Barykina, N. V., Subach, O. M., Sotskov, V. P., Plusnin, V. V., Ivleva, O. A., Isaakova, E. A., Varizhuk, A. M., Pozmogova, G. E., Malyshev, A. Y., Smirnov, I. V., Piatkevich, K. D., Anokhin, K. V., Enikolopov, G. N., Subach, F. V., Piatkevich, Kiryl
Other Authors: Massachusetts Institute of Technology. Media Laboratory
Format: Article
Language:English
Published: BioMed Central 2018
Online Access:http://hdl.handle.net/1721.1/114454

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http://hdl.handle.net/1721.1/114454

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