Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated with neurodegenerative disorders, including Alzheimer’s disease. Previously, we showed that replacing endogenous p35 with the noncleavabl...

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Bibliographic Details
Main Authors: Silva, M. Catarina, Sheridan, Steven D., Lucente, Diane, Gusella, James F., Dickerson, Bradford C., Haggarty, Stephen J., Tsai, Li-Huei, Seo, Jinsoo, Kritskiy, Oleg, Watson, Lauren Ashley, Barker, Scarlett Jazmine, Dey, Dilip Chandra, Raja, Waseem K, Lin, Yuan-Ta, Ko, Tak, Cho, Sukhee, Penney, Jay
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Published: Society for Neuroscience 2018
Online Access:http://hdl.handle.net/1721.1/114504
https://orcid.org/0000-0003-2237-1569
https://orcid.org/0000-0002-5452-2352
https://orcid.org/0000-0002-2461-1135
https://orcid.org/0000-0001-5607-113X
https://orcid.org/0000-0003-1262-0592

Internet

http://hdl.handle.net/1721.1/114504
https://orcid.org/0000-0003-2237-1569
https://orcid.org/0000-0002-5452-2352
https://orcid.org/0000-0002-2461-1135
https://orcid.org/0000-0001-5607-113X
https://orcid.org/0000-0003-1262-0592

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