A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow
Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2018
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| Online Access: | http://hdl.handle.net/1721.1/114538 https://orcid.org/0000-0001-7266-9350 https://orcid.org/0000-0001-5511-5620 https://orcid.org/0000-0002-8601-7799 https://orcid.org/0000-0001-7192-580X |