Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

Protein-based methods of siRNA delivery are capable of uniquely specific targeting, but are limited by technical challenges such as low potency or poor biophysical properties. Here, we engineered a series of ultra-high affinity siRNA binders based on the viral protein p19 and developed them into siR...

Full description

Bibliographic Details
Main Authors: Sun, Fangdi, Yang, Lucy F., Traxlmayr, Michael W., Yu, Yao, Xu, Yingda, Yang, Nicole Jie Yeon, Kauke, Monique Jacqueline, Maass, Katie F, Langer, Robert S, Anderson, Daniel Griffith, Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Oxford University Press (OUP) 2018
Online Access:http://hdl.handle.net/1721.1/114564
https://orcid.org/0000-0002-0882-7761
https://orcid.org/0000-0002-0013-3941
https://orcid.org/0000-0002-0493-2863
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-2398-5896

Internet

http://hdl.handle.net/1721.1/114564
https://orcid.org/0000-0002-0882-7761
https://orcid.org/0000-0002-0013-3941
https://orcid.org/0000-0002-0493-2863
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-2398-5896

Similar Items