Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Certain RGD-binding integrins are required for cell adhesion, migration, and proliferation and are overexpressed in most tumors, making them attractive therapeutic targets. However, multiple integrin antagonist drug candidates have failed to show efficacy in cancer clinical trials. In this work, we...

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Bibliographic Details
Main Authors: Dranoff, Glenn, Kwan, Byron Hua, Zhu, Eric Franklin, Tzeng, Alice, Sugito, Harun R., Eltahir, Ahmed A., Ma, Botong, Delaney, Mary K., Murphy, Patrick A., Kauke, Monique Jacqueline, Angelini, Alessandro, Momin, Noor, Mehta, Naveen, Maragh, Alecia M., Hynes, Richard O., Cochran, Jennifer R., Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Rockefeller University Press 2018
Online Access:http://hdl.handle.net/1721.1/114593
https://orcid.org/0000-0002-9851-7029
https://orcid.org/0000-0003-3789-1516
https://orcid.org/0000-0001-7316-6923
https://orcid.org/0000-0002-0013-3941
https://orcid.org/0000-0001-5923-3843
https://orcid.org/0000-0003-3145-6089
https://orcid.org/0000-0003-3480-6750
https://orcid.org/0000-0001-7603-8396
https://orcid.org/0000-0003-2398-5896

Internet

http://hdl.handle.net/1721.1/114593
https://orcid.org/0000-0002-9851-7029
https://orcid.org/0000-0003-3789-1516
https://orcid.org/0000-0001-7316-6923
https://orcid.org/0000-0002-0013-3941
https://orcid.org/0000-0001-5923-3843
https://orcid.org/0000-0003-3145-6089
https://orcid.org/0000-0003-3480-6750
https://orcid.org/0000-0001-7603-8396
https://orcid.org/0000-0003-2398-5896

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