Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model
Background Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver...
Main Authors: | , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
BioMed Central
2018
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Online Access: | http://hdl.handle.net/1721.1/114617 https://orcid.org/0000-0003-1080-4005 https://orcid.org/0000-0002-0339-3685 |