Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

Background Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver...

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Bibliographic Details
Main Authors: Li, Huipeng, Venkatraman, Lakshmi, Narmada, Balakrishnan C, Tucker-Kellogg, Lisa, Narmada, Balakrishnan Chakrapani, White, Jacob K, Yu, Hanry
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: BioMed Central 2018
Online Access:http://hdl.handle.net/1721.1/114617
https://orcid.org/0000-0003-1080-4005
https://orcid.org/0000-0002-0339-3685

Internet

http://hdl.handle.net/1721.1/114617
https://orcid.org/0000-0003-1080-4005
https://orcid.org/0000-0002-0339-3685

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