Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture

Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture

During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and adopts an unusual 3D configuration known as the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D conformation. We recently showed that in humans the Xi c...

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Bibliographic Details
Main Authors: Darrow, Emily M., Huntley, Miriam H., Dudchenko, Olga, Stamenova, Elena K., Durand, Neva C., Sun, Zhuo, Huang, Su-Chen, Sanborn, Adrian L., Machol, Ido, Shamim, Muhammad, Seberg, Andrew P., Chadwick, Brian P., Aiden, Erez Lieberman, Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Proceedings of the National Academy of Sciences 2018
Online Access:http://hdl.handle.net/1721.1/114761

Internet

http://hdl.handle.net/1721.1/114761

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