Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality

Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality

Downstream metabolic events can contribute to the lethality of drugs or agents that interact with a primary cellular target. In bacteria, the production of reactive oxygen species (ROS) has been associated with the lethal effects of a variety of stresses including bactericidal antibiotics, but the r...

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Bibliographic Details
Main Authors: Liu, Xiaobo, Andreescu, Silvana, Takahashi, Noriko, Gruber, Charley C, Yang, Jason Hung-Ying, Braff, Dana, Yashaswini, Chittampalli N., Bhubhanil, Sakkarin, Furuta, Yoshikazu, Collins, James J., Walker, Graham C.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: National Academy of Sciences (U.S.) 2018
Online Access:http://hdl.handle.net/1721.1/114885
https://orcid.org/0000-0002-7127-9833
https://orcid.org/0000-0003-0921-4657
https://orcid.org/0000-0003-4710-1389
https://orcid.org/0000-0002-5560-8246
https://orcid.org/0000-0001-7243-8261

Internet

http://hdl.handle.net/1721.1/114885
https://orcid.org/0000-0002-7127-9833
https://orcid.org/0000-0003-0921-4657
https://orcid.org/0000-0003-4710-1389
https://orcid.org/0000-0002-5560-8246
https://orcid.org/0000-0001-7243-8261

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