Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

Rett syndrome (RTT) arises from loss-of-function mutations in methyl-CpG binding protein 2 gene (Mecp2), but fundamental aspects of its physiological mechanisms are unresolved. Here, by whole-cell recording of synaptic responses in MeCP2 mutant mice in vivo, we show that visually driven excitatory a...

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Bibliographic Details
Main Authors: Tang, Xin, Li, Chenchen, Fu, Zhanyan, Jaenisch, Rudolf, Banerjee, Abhishek, Rikhye, Rajeev Vijay, Breton-Provencher, Vincent, Li, Keji, Runyan, Caroline Anne, Sur, Mriganka
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Published: National Academy of Sciences (U.S.) 2018
Online Access:http://hdl.handle.net/1721.1/114900
https://orcid.org/0000-0003-2011-2897
https://orcid.org/0000-0002-1701-325X
https://orcid.org/0000-0002-0737-2558
https://orcid.org/0000-0003-2442-5671

Internet

http://hdl.handle.net/1721.1/114900
https://orcid.org/0000-0003-2011-2897
https://orcid.org/0000-0002-1701-325X
https://orcid.org/0000-0002-0737-2558
https://orcid.org/0000-0003-2442-5671

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