Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines

Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines

AAA+ proteases and remodeling machines couple hydrolysis of ATP to mechanical unfolding and translocation of proteins following recognition of sequence tags called degrons. Here, we use single-molecule optical trapping to determine the mechanochemistry of two AAA+ proteases, Escherichia coli ClpXP a...

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Bibliographic Details
Main Authors: Olivares, Adrian O., Kotamarthi, Hema Chandra, Stein, Benjamin Joseph, Sauer, Robert T., Baker, Tania
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: National Academy of Sciences (U.S.) 2018
Online Access:http://hdl.handle.net/1721.1/114914
https://orcid.org/0000-0001-9751-9535
https://orcid.org/0000-0002-2246-2674
https://orcid.org/0000-0002-1719-5399

Internet

http://hdl.handle.net/1721.1/114914
https://orcid.org/0000-0001-9751-9535
https://orcid.org/0000-0002-2246-2674
https://orcid.org/0000-0002-1719-5399

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