A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) n Repeats Associated with Friedreich’s Ataxia

A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA) n Repeats Associated with Friedreich’s Ataxia

Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich's ataxia. Whereas the length of an expandable repeat is the main factor determining disease inheritance, recent data point to genomic trans modifiers that...

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Bibliographic Details
Main Authors: McGinty, Ryan J., Puleo, Franco, Aksenova, Anna Y., Hisey, Julia A., Shishkin, Alexander A., Pearson, Erika L., Moore, Claire, Mirkin, Sergei M., Wang, Eric T, Housman, David E
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/114933
https://orcid.org/0000-0001-5016-0756

Internet

http://hdl.handle.net/1721.1/114933
https://orcid.org/0000-0001-5016-0756

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