3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resol...

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Bibliographic Details
Main Authors: Brignole, Edward J, Tsai, Kuang-Lei, Chittuluru, Johnathan, Li, Haoran, Aye, Yimon, Penczek, Pawel A, Stubbe, JoAnne, Drennan, Catherine L., Asturias, Francisco
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: eLife Sciences Publications, Ltd 2018
Online Access:http://hdl.handle.net/1721.1/114937
https://orcid.org/0000-0002-4285-6128
https://orcid.org/0000-0001-8076-4489
https://orcid.org/0000-0001-5486-2755

Internet

http://hdl.handle.net/1721.1/114937
https://orcid.org/0000-0002-4285-6128
https://orcid.org/0000-0001-8076-4489
https://orcid.org/0000-0001-5486-2755

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