3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound
Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resol...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
eLife Sciences Publications, Ltd
2018
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| Online Access: | http://hdl.handle.net/1721.1/114937 https://orcid.org/0000-0002-4285-6128 https://orcid.org/0000-0001-8076-4489 https://orcid.org/0000-0001-5486-2755 |